About Us

The main aim of the mycochemistry research group based at Stellenbosch Tygerberg Medical School and the South African Medical Research Council Centre for TB Research is to discover novel biopharmaceuticals that can be used against Mycobacterium tuberculosis. We are interested in the intersection of Host Directed Therapeutics (HDT) and Classical Drug Discovery where attempts to enhance host-mediated responses to mycobacteria are implement rather than acting directly on the pathogen. We use a plethora of sources such as bacterial and fungal endophytes from plants endemic to Gaansbai, marine fungal and bacterial symbionts (Saldanha Bay, Simonstown and De Kelders) from invasive ascidians and marine sponges and fungi associated with gold mine tailings. Pure compounds obtained from these sources are either bioprocessed further, used as they are to target neutrophils, Mycobacterium tuberculosis infected macrophages and ultimately on zebrafish infected with Mycobacterium marinum and most importantly, used to formulate magnetite nanoparticles to target Mycobacterium tuberculosis..